|
KMID : 0861120040080010109
|
|
Korean Journal of Oriental Preventive Medicine
2004 Volume.8 No. 1 p.109 ~ p.114
|
|
|
Effects of ginkgo Biloba Extracts on Rthanol and Acetaldehyde-induced Oxidative Stress in Rat Brain
|
|
Park Seong-Uk
Kim Jong-Bong
Heo Yong
Lee Sun-Dong
Kim Hee-Jung
Lee In-Seon
Han Jung-Ho
Park Yeong-Chul
|
|
|
Abstract
|
|
|
|
Oxidative stress is one of the major reasons for brain aging and neurodegeneration. Ethanol and acetaldehyde increase the levle of oxidative stress in brain tissue resulting in aging and neurodegeneration related alcoholic dementia. Ginkgo biloba extracts are used as therapeutic and preventive agent for dementia. Here, it was investigated whether Ginkgo biloba extract show the effectiveness against ethanol- and acetaldehyde-induced oxidative stress in rat brain. Ethanol and acetaldehyde increased the level of oxidative stress by about 35% to 50% in rat brain tissue. However, Ginkgo biloba extracts reduced the level of ethanol- and acetaldehyde-induced oxidative stress. This result might reveal the link between the effectiveness of Ginkgo biloba extracts on oxidative stress and its effectiveness on alcoholic dementia.
|
|
|
KEYWORD
|
|
|
Ethanol, Acetaldehyde, Rat Brain, Oxidative Stress, Ginkgo Biloba Extracts
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|